Eqtl meta analysis
WebOct 19, 2024 · Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis, bioRxiv, 2024-10-19 Friday, Oct 19, 2024. Code. Show All Code; Hide All Code; Paper Info ... LDA topic modeling analysis. We obtained a list of tweets/RTs referencing the specified article by querying the Crossref Event Data API. For each … WebNov 28, 2014 · To our knowledge, meta-eqtl is the first software to perform meta-analysis on arbitrary number of eQTL datasets. We thus compared our results with those obtained with METAL [],[], a tool which performs meta-analysis on pre-stored test statistics.On a data of four individual sets (sample size of 1000, 1000, 500 and 500, respectively), we tested …
Eqtl meta analysis
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WebAug 25, 2024 · Background Advances in the expression quantitative trait loci (eQTL) studies have provided valuable insights into the mechanism of diseases and traits-associated genetic variants. However, it remains challenging to evaluate and control the quality of multi-source heterogeneous eQTL raw data for researchers with limited computational … WebExpression quantitative trait loci (eQTL) can provide a link between disease susceptibility variants discovered by genetic association studies and biology. To date, eQTL mapping studies have been primarily conducted in healthy individuals from population-based cohorts. Genetic effects have been known to be context-specific and vary with changing …
WebAfter QC, imputation, association test, and meta-analysis of 2 GWAS datasets, I identified three novel susceptibility loci for IBD using a total of 3,195 cases and 4,419 controls in Koreans (Jung ... WebOct 1, 2024 · Fig. 1 eQTL meta-analysis discov ers more eQTL than individual cohorts. ( a ) Quantile-quantile plo t of eQTL from individual cohorts as well as the meta-analysis of the true (black) an d permuted ...
WebSep 11, 2024 · We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits. PTWAS applies the established principles from instrumental variables analysis and takes advantage of probabilistic eQTL annotations to delineate … WebJan 31, 2024 · The meta-analysis eQTL dataset included 201,627,059 associations with a total sample size of n = 686. Based on this new database, we identified 10,430 genes with eQTLs, of which 11% (1,146) …
WebJoint statistical fine-mapping of eQTL and GWAS identified 329 variant-trait pairs for 24 brain-related traits driven by 204 unique candidate causal variants for 189 unique genes. …
WebOct 22, 2024 · Results for eQTL and sQTL meta-analysis and colocalization Katia de Paiva Lopes; Towfique Raj This dataset is part of the manuscript: " Atlas of genetic effects in human microglia transcriptome across brain regions, aging and disease pathologies ", by Lopes KP, Snijders GJL, Humphrey J, et al. Description of files: check mark in typehttp://www.susztaklab.com/Kidney_eQTL/index.php flat black vulcan motorcycleWebOct 7, 2014 · All existing cortical eQTL studies are small and emphasize the need for a meta-analysis. We performed a meta-analysis of 424 brain samples across five studies to … Current catalogs of brain expression quantitative trait loci (eQTL) are incomplete and the findings do not replicate well across studies. check mark in times new romanWebApr 23, 2015 · For mapping eQTLs in a cross-population meta-analytic setting, we make an important assumption that if a SNP is genuinely associated with a given expression phenotype, its underlying genetic effects are non-zero in all population groups. That is, γ = 1, if SNP j is an eQTL, and 0 otherwise. flat black vinyl wrap carWebeQTpLot is an intuitive and user-friendly R package developed for the visualization of colocalization between eQTL and GWAS data. eQTpLot takes as input standard GWAS and eQTL summary statistics, and optional pairwise LD information, to generate a series of plots visualizing colocalization, correlation, and enrichment between eQTL and GWAS … flat black vinyl sheetsWebResults: Meta-analysis of 9953 females combining discovery (N = 4658) and replication (N = 5295) stages detected four (rs11162584, rs6760543, rs828104, rs56137030), six (rs139702234, rs2341967, rs73059848, rs5020945, ... If a variant is not an eQTL, the gene in which a variant is located or closest to a variant is assigned as the candidate gene check mark in whatsappWebJul 7, 2024 · Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models - PMC Back to Top Skip to main content An … check mark invisible background